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艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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艾美捷科技代理42 life sciences品牌全系列产品


42 life sciences是一家位于德国北部不来梅港的中小型企业。42 life sciences专注于开发和生产用于免疫组化(IHC)及原位杂交(ISH)应用的创新试剂。公司的核心优势在于拥有经验丰富的生物技术专家团队,确保产品开发高效聚焦,同时以可靠且具成本效益的方式进行生产。所有研发与制造流程均在我们自有设施中严格遵循EN ISO9001和EN ISO 13485标准执行。

42 life sciences公司的产品与服务包括:免疫组化与原位杂交创新试剂;外包生物缓冲液及试剂的生产业务。


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▎42 life sciences产品列表

分类品名产品描述货号规格
Chromogens for HRPAEC Solution IHC (ready-to-use)AEC (3-Amino-9-Ethylcarbazole) is a commonly used chromogen for immunohistochemical (IHC) procedures supplied in one liquid component.S-99012-100;S-99012-1000100ml;1000ml
Chromogens for HRPAEC Solution ISH (ready-to-use)AEC (3-Amino-9-Ethylcarbazole) is a commonly used chromogen for chromogenic in situ hybridization (CISH) procedures supplied in one liquid component.S-99010-500;S-99010-1000500ml;1000ml
Chromogens for HRPDAB Solution Set (2 components)DAB (3,3‘-diaminobenzidine) is a widely used chromogen in immunohistochemical and immunoblotting applications.S-99014-103;S-99014-1030103ml;1030ml
Chromogens for HRPHRP-Green Solution Set (2 components)The HRP-Green Solution Set is a new chromogen used in immunohistochemical and chromogenic in situ hybridization applications.S-99056-103;S-99056-1030103ml;1030ml
Chromogens for HRPHRP-Green Solution Set (MxE)The HRP-Green Solution Set (MxE) is a unique chromogen used in immunohistochemical and chromogenic in situ hybridization applications that is mixable in equal parts.S-99070-100;S-99070-2000100ml;2000ml
Chromogens for HRPAP-Red Solution Set IHC (2 components)The AP-Red Solution Set IHC is a chromogen used in immunohistochemical applications.S-99065-103103ml
Chromogens for HRPAP-Red Solution Set ISH (2 components)The AP-Red Solution Set ISH is a chromogen used in chromogenic in situ hybridization applications.S-99061-10301030ml
Chromogens for HRPNBT/BCIP Solution (ready-to-use)The NBT/BCIP Solution is a chromogen used in immunohistochemical and chromogenic in situ hybridization applications.S-99064-500500ml
CounterstainsMayer`s Hematoxylin Solution (ready-to-use)Mayer’s Hematoxylin Solution is a staining reagent for histological applications.S-99025-10001000ml
CounterstainsNuclear Blue Solution (ready-to-use)Nuclear Blue Solution is a hematoxylin based reagent for counterstaining applications in in situ hybridization (ISH) and immunohistochemistry (IHC) procedures using common chromogens like AEC and DAB.S-99035-10001000ml
CounterstainsNuclear Fast Red Solution (ready-to-use)Nuclear Fast Red Solution is designed for use as a counterstaining solution in immunohistochemistry (IHC) procedures using common chromogens like BCIP/NBT.S-99031-10001000ml
CounterstainsNuclear Red Solution (ready-to-use)Nuclear Red Solution is a nuclear fast red (a.k.a. Kernechtrot) based reagent for counterstaining applications in in situ hybridization (ISH) and immunohistochemistry (IHC) procedures.S-99033-500;S-99033-1000500ml;1000ml
CounterstainsNuclear Green Solution (ready-to-use)Ready-to-use Nuclear Green Solution optimized for the use in immunohistochemical (IHC) and in situ hybrididzation (ISH) procedures. Suitable for aqueous and non- aqueous mountants.S-99104-10001000ml
Ancillary Reagents1% BSA Ab Diluent (ready-to-use)The 1% BSA Ab Diluent is a stabilizer and diluent for all antibodies routinely used in immunohistochemistry (IHC) and in situ hybridization (ISH) applications.S-99068-10001000ml
Ancillary Reagentsone4all-Antibody Stabilizer (ready-to-use)The one4all-Antibody Stabilizer is a unique stabilizer for all antibody-enzyme conjugates routinely used in immunohistochemistry (IHC) and in situ hybridization (ISH) applications as well as in ELISA.S-99030-10001000ml
Ancillary ReagentsPepsin Solution (ready-to-use)Pepsin is a commonly used digestive enzyme for immunohistochemical (IHC) and in situ hybridization (ISH) procedures.S-99003-50;S-99003-500;S-99003-100050ml;500ml;1000ml
Ancillary ReagentsPepsin Solution for Cytology (ready-to-use)Pepsin Solution for Cytology is a digestive enzyme solution used in in situ hybridization (ISH) procedures in cytology specimens.S-99053-500;S-99053-1000500ml;1000ml
Ancillary ReagentsProteinase K Solution (ready-to-use)The Proteinase K Solution is specifically designed for use in the pretreatment of formalin-fixed tissue for in situ-hybridization (ISH) procedures.S-99080-100100ml
Ancillary ReagentsDuraTect™ DAPI/Antifade Solution (ready-to-use)The DuraTect™ DAPI/Antifade Solution is a refrigerator-stable formula for preserving fluorescence.S-99081-10;S-99081-100;S-99081-50010ml;100ml;500ml
Ancillary ReagentsDuraTect™ DAPI/Antifade Solution "ultra" (ready-to-use)The DuraTect™ DAPI/Antifade Solution "ultra" is a refrigerator-stable formula for preserving fluorescence.S-99098-5050ml
Ancillary ReagentsCOT-DNA, human (10mg/ml)The COT fraction of human genomic DNA predominantly consists of rapidly annealing repetitive sequences.S-99040-1;S-99040-10;S-99040-501mg;10mg;50mg



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ViroStat.jpg

ViroStat于1985年,由Douglas McAllister博士创立,致力于为研究者和工业界提供传染性疾病的抗体产品。产品线涵盖病毒学、细菌学和寄生虫学,应用于呼吸道药、性病药、胃肠药/毒素和食源性致病菌的检测。ViroStat拥有超过500种传染性疾病相关的试剂,其中包括MONOTOPE系列单克隆抗体、PMNITOPE多克隆抗体和数量众多的重组蛋白抗原。基于长期的经验积累,ViroStat能够提供从100ug到10g级别的产品。

 

ViroStat was founded in 1985 by Dr. Douglas McAllister to provide infectious disease antibody tools to researchers and manufacturers. These include the areas of virology, bacteriology and parasitology. Applications for these include detection of respiratory agents, STD agents, gastrointestinal agents/toxins and food borne pathogens.

 

The company offers more than 500 infectious disease reagents including their MONOTOPE™ monoclonal antibodies, OMNITOPE™ polyclonal antibodies and numerous recombinant antigens. Many of these antibodies are used by manufacturers of rapid, point of care tests currently made and sold in the US.

 

ViroStat公司产品包括:

MONOTOPE™ - Monoclonal Antibodies (Mouse) 小鼠单克隆抗体

RABMAB® - Monoclonal Antibodies (Rabbit) 兔单克隆抗体

OMNITOPE™ - Polyclonal Antibodies多克隆抗体

RECOMBINANT ANTIGENS 重组抗原

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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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immunoGlobe GmbH.jpg

immunoGlobe GmbH成立于1997年,主要业务包括:1)生产研究用蛋白(特别关注信号转导及细胞骨架);2)对学术机构提供的优良抗体进行商业化;3)提供定制的多克隆抗体生产和纯化。

 

Our Mission is to supply the Scientific Community with affordable high quality research antibodies and reagents. Towards this goal we are pursuing three major fields, since 1997:

 

Manufacturing of novel research antibodies (with a focus on signal transduction and the cytoskeleton). More than 50% of the still limited but constantly expanding product portfolio are unique research antibodies available from no other commercial source.

 

Commercialization of well characterized and established antibodies developed and licensed by our university partners. immunoGlobe® takes over packing, documentation, marketing, and distribution of the products. The company especially benefits also from the marketing activities of its world-wide distributors.

 

Production & affinity purification of polyclonal custom antibodies (antibody services). imunoGlobe has been one of the first service providers to offer fractional affinity purification with multiple columns! Based on sophisticated purification strategies, our special focus is on the generation of antibodies directed against modifications.

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更多详情请联系 

艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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